Program

October 8, 2014

14:00                         Welcome

Protein-protein Interactions and Systems Biology      

14:10-15:10       Emmanuel LEVY – Weizmann Institute of Science, Rehovot, Israel

                            “Promiscuous protein-protein interactions: a burden for the cell and a tool for the biologist”

15:10-16:10        Shoshana WODAK - University of Toronto, Canada

                               “Protein-protein interaction data: All that glitters is not gold”

16:10-16:40       Coffee break

16:40-17:40        Patrick ALOY - Institute for Research in Biomedecine, Barcelona, Spain

                              “Structural Systems Pharmacology: the role of 3D structures in next generation drug

                               development”

October 9, 2014

Protein design principles

9:00-10:00        Gideon SCHREIBER – Weizmann Institute of Science, Rehovot, Israel

                            “Connecting the dots:  relevance of binding kinetics and affinities in dictating biological

                              processes in the complex in-vivo environment”

10:00-10:30       Coffee break

10:30-11:30        Rama RANGANATHAN – University of Texas, Southwestern Medical Center, Dallas, USA

                              “The Evolutionary Design of Proteins”

11:30-12:30        Juan FERNANDEZ-RECIO  – Barcelona Supercomputing Center, Barcelona, Spain

                              “Functional characterization and modeling of protein-protein interfaces: lessons from docking”

12:30-14:15       Lunch and coffee

Protein affinities and specificities

14:15-15:15        Alexandre BONVIN – Utrecht University, The Netherlands

                              “Modelling structure, affinity and specificity of biomolecular complexes”

15:15-16:15       Alan COOPER - University of Glasgow, UK

                             “Experimental Thermodynamics of Proteins and their Interactions”

16:15-16:45         Coffee break

Proteins in the cell

16:45-17:45        Eugene SHAKHNOVICH – Harvard University, Cambridge, USA

                              “Protein-protein interactions in living cells: fitness costs and benefits of finding the

                               right partners and avoiding the wrong ones”

October 10, 2014

Molecular docking

9:15-10:15        Martin ZACHARIAS – Technische Universität München, Germany

                           “Exploring protein-protein interactions by coarse-grained and atomistic models”

10:15-10:45       Coffee break

10:45-11:45       Zhiping WENG - University of Massachusetts Medical School, USA

                            “Protein-protein docking and design”

11:45-12:45        Matteo DAL PERARO – École Polytechnique Fédérale de Lausanne, Switzerland

                              “Unveiling the structure of macromolecular assemblies using integrative dynamic modeling”

                                                                               End of the meeting